From Sequence Reads to Achievements

genxpro_home_icon_bioinformaticsOur team of bioinformaticians has developed sophisticated pipelines to extract every bit of information of your data. Our pipelines consist of rigourous and smart error correction strategies, highly sensitive mapping and annotaion steps while prompting the entire availble information from all open databases, and a convenient to analyse data output.  We are chosen by leading acadmic and commercial research units wolrd wide as partners for data analysis and have succefully contributed to numerous publications. Besides, we have also designed our own web-based and highly accessed analysis tools, availble for everyone (omiRas and APADB).

Our web suite navigates you through your own data and connects and compares them with the known data from databases world wide.

The data are generated such that you can follow up all steps of the analysis, from raw data to biological pathways and functions.  We are also integrating  many existing  tools for data and metadata -analysis such as KEGG, GO or Reactome Pathway.

Data can be delivered in all usual formats, the analyses usually in a table which can readily be analysed using Excel. Data  is provided conveniently via secured FTP or by shipping of a hard-disk.

Sophisticated analysis pipelines for data from all organisms:

  • RNA-Seq
  • Mapping / Annotation using all availbale nucleotide and protein resources
  • Identification of isoforms, splicing & fusion genes, SNPs
  • De Novo Assembly
  • Quantification of transcripts / p-values for differential gene expression
  • Gene Set Enrichment Analyses (GSEA)
  • Gene Ontology annotation & Enrichment Analyses

Human DNA and RNA – quickly find what others already know

By constantly evaluating and collecting the available information from the many different open source databases and publications, we have generated a huge knowledge base of functional  annotations, which we are constantly feeding with further information. The database is for research use only. We provide fast access to the available clinical information from

  • Variants, CNVs and Fusions
  • small RNAs
  • gene expression data
  • epigenetic data

 

Machine Learning: Finding what matters in the data jungle!

With the help of advanced machine learning and deep learning techniques such as Random Forest, we pinpoint precisely the causative players from the myriad of genomic datasets available online and generated in-house.
Our know-how is fundamental for precision medicine and therapeutic decisions, to determine and classify  important subsets of genes, mutations or epigenetic changes. We apply our machine-learning expertise also to any other area with similar data structure, such as for metagenomics or for plant breeding.

Genome and Exome

  • SNPs
  • Indels
  • Rearrangements
  • Copy Number Variations (CNVs)
  • Genotyping
  • Generation of linkage maps
  • QTL analyses
  • Genomic Selection

Microbiome

  • Annotation / identification of organisms
  • Annotation to protein databases
  • Quantification of organisms
  • Graphical representation of the data

PCR  Bias Elimination

as inventors of the TrueQuant method, we can identify and eliminate PCR introduced copies and bias, for much better quantification and more reliable mutation calling.

Druggability Analyses / Theranostics

our unique analyses tool identifies differential regulated transcripts, translates them into biological pathways and identifies in the vast repertoire of exisiting drugs the ones with the strongest likelyhood to intervene in these pathways.

New therapeutic options become visible in a few mouse clicks.

All the information onto which the decision is based are clearly documented and links to the databases,research papers,  drugs and genes are provided for fast and comprehensive information.

Any special Requests ?

Together with our customers we develop also tailored analysis modules for your specific needs.  Our pipelines are also open for data that was generated independently from us. Please do not hesitate to contact us with special requests or for the interpretation of your own NGS data.

 

Access to your data and the analysis platform at: http://tools.genxpro.net