State of the Art Bioinformatics for all your NGS Data
Unleash the Full Potential of Next-Generation Sequencing: Simply upload your NGS Illumina raw-data or fastqc data to our webserver, start the required analyses and receive your results a few minutes to hours later.
We are chosen by leading academic and commercial research units worldwide as partners for data analysis and have successfully contributed to numerous publications.
We offer
Data Preprocessing – Demultiplexing, clean, filter, and quality-check of the data
Alignment and Variant Calling – Alignment of sequences to the reference genome of choice and identification of genetic variations, gene counts, transcript counts, p-values and other features, plots and quality information
Data Interpretation – Complex algorithms and analytical tools for convenient access to comprhensive insights
Our powerful analyses pipelines are available for
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Whole Genome Sequencing (WGS)
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Whole Exome Sequencing (WES)
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RNA-Seq
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MACE-Seq (3′ mRNA-Seq)
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smallRNA-Seq
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Microbiome
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Amplicons & Aptamers
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Customized bioinformatics solutions
Fast access to the actual state of knowledge by comprehensive annotation to numerous publicly available databases
By constantly evaluating and collecting the available information from the many different open source databases and publications, we have generated a huge knowledge base of functional annotations, which we are constantly feeding with further information. The database is for research use only. We provide fast access to the available clinical information from
Machine Learning: Finding what matters in the data jungle!
With the help of advanced machine learning techniques and deep learning we pinpoint causative players from the myriad of genomic datasets available online and generated in-house.
Our know-how is fundamental for precision medicine and therapeutic decisions, to determine and classify important subsets of genes, mutations or epigenetic changes.
Genome and Exome
- SNPs
- Indels
- Rearrangements
- Actionable mutations (e.g. EGFR, ALK, ROS1, RET, MET, NTRK, BRAF KRAS)
- Copy Number Variations (CNVs)
- germline and somatic variants
- Homologous Recombination Deficiency (HRD)
- Loss of Heterozygosity (LOH)
- Large Scale Transitions (LST)
- Telomeric Allelic Imbalance (TAI)
- Microsatellite Instability (MSI)
- Tumor Mutational Burden
- Mutation Signatures
- HLA Status
- Neoepitopes
- Genotyping
- Generation of linkage maps
- QTL analyses
- Genomic Selection
Microbiome
- Annotation / identification of organisms
- Annotation to protein databases
- Quantification of organisms
- Graphical representation of the data
Druggability Analyses / Theranostics
Our unique analyses tool identifies differential regulated transcripts, translates them into biological pathways and identifies in the vast repertoire of existing drugs the ones with the strongest likelihood to intervene in these pathways.
New therapeutic options become visible in a few mouse clicks
All the information onto which the decision is based are clearly documented and links to the databases, research papers, drugs and genes are provided for fast and comprehensive information.
Primer design
We apply algorithms from NGS data analyses pipelines to quickly identify uniqe genetic information, for example from a species or variant within a microbiome, that we use to design highly specific primer pairs for PCR and qPCR assays.
Plant research and breeding, model and non-model organisms
We are chosen by numerous breeding companies and institutes world-wide for NGS bioinformatics analyses in the field of plant-breeding. Our unique annotation pipeline includes all available protein information as well as data from related species for the most accurate identification of genes of a trait of interest from genomics and transcriptomics data. We are specialists for do-novo assemblys, GBS, QTL and eQTL analyses of model and non-model plants and organisms.
Our web suite navigates you through your own data and connects and compares them with the known data from databases worldwide.
Data can be delivered in all usual formats, the final results typically in a table which can readily be analyzed using Excel. Data is provided conveniently via secured FTP or by shipping of a hard-disk.
Any special Requests?
Collaboration: Engage with our experts, tapping into their knowledge to drive your research forward.
Together with our customers we develop tailored analysis modules for your specific needs. Our pipelines are also open for data that was generated independently from us. Please do not hesitate to contact us with any special requests or for the interpretation of your NGS data.
Please feel free to access examplary data on our server at https://tools.genxpro.net
Login: TUser
Password: testtest
Important note
All services are for research use only (RUO) .The results can not be used for diagnostic purposes or therapeutic decision support. All data that are uploadd to our servers must be legally obtained under consideration of all rights of the donor including ethical rights and local legislatition. We cannot be made responsible for any breach of such rights or legislation.
